Columbia University Dissertations: Dissertations

Biochemistry and Molecular Biophysics: Dissertations

2006 - 2005 - 2004 - 2003 - 2002 - 2001 - 2000 - 1999 - 1998 - 1997 - 1996 - 1995 - 1994

2006 DISSERTATIONS

Butterwick, Joel (2006) On the dynamics of thermophilic proteins : interrelationships between form, flexibility and function

Chen, Chien (2006) Theoretical and experimental insights into specificity determinants and molecular mechanisms of cadherin mediated adhesion

Khalil, Mona (2006) Mast cell interactions with the CNS

Soto, Cinque Sam (2006) Advances in the rapid predition of loop conformation in proteins

Valentine, Elizabeth (2006) NMR dynamics of the GluR2 ionotropic glutamate receptor ligand binding core/

2005 DISSERTATIONS

Cheung, Jonah (2005) A structural genomics analysis of histidine kinase sensor domains

De Lencastre, Alexandre (2005) Exploring the structure of a group II intron using interference mapping, suppression, and photocrosslinking

Grey, Michael (2005) Characterizing conformational changes in protein using NMR spin relaxation dispersion : theory, methods, and applications

Johnston, Robert (2005) A bistable feedback loop of microRNAs and transcrition factors controls neuronal left/right asymmetry in C. elegans

Kawate, Toshimitsu (2005) Biochemical and structural studies of P2X receptors

Kim, Michelle (2005) Pheromone detection and its role in mating and aggression

Myer, Benjamin (2005) Intravaginal practices, bacterial vaginosis and cervical epithelial disruptions : risk factors for HIV infection among South African

Nair, Rajesh (2005) Computational prediction of subcellular localization of proteins

Przybylski, Dariusz (2005) Prediction-based improvements of protein fold recognition and alignment quality

Siggers, Trevor (2005) Aligning and modeling protein-DNA interfaces : towards an understanding of protein-DNA binding specificity

2004 DISSERTATIONS

Chen, Jiabin (2004) Sel-7 and sel-13, two positive regulators of lin-12 activitiy in Caenorhabditis elegans

Emtage, Lesley (2004) Interactions between extracellular matrix molecules and the mechanosensory channel complex in C. elegans touch-sensing neurons

Gimpelev, Marina (2004) Helical packing patterns in transmembrane and water-soluble proteins

Kim, Hyeong Chan (2004) Biochemical and genetic studies of coliphage HK022-encoded transcription termination facotr, Nun protein

Mehta, Nehal (2004) Genetic analysis of axon outgrowth in Caenorhabditis elegans

Montoya, Michelle (2004) Insights into membrane association and bioengineering of a pore-forming toxin : structural studies of Staphylococcal α-Hemolysin

Ofram, Yanay (2004) Analysis and prediction of contacting residues in protein-protein interfaces

Olivier, Nelson (2004) Structural studies of the post S6 cyclic nucleotide binding region of HCN2

Patel, Saurabh (2004) High-resolution structural studies of resistin, and adipocyte-secreted hormone that induces insulin resistance

2003 DISSERTATIONS

Jin, Rongsheng (2003) Structural and functional studies of the GluR2 receptor

Olson, Richard (2003) Structural insights into the mechanism and specificity of pore-forming toxins from Staphylococcus aureus and Vibrio cholerae

2002 DISSERTATIONS

Duarte, Carlos (2002) Computational approaches to the analysis and prediction of RNA structure

Hinrichs-Sterling, Karen (2002) The role of v-Abl tyrosine kinase in transformation and apoptosis

Lomvardas, Stavros (2002) Chromatin structure and gene transcription

Pang, Phillip (2002) Characterization of the Hepatitis C viral helicase and a sequence analysis algorithm that predicts functional interactions

Petrey, Donald (2002) Energetics and visualization of biological macromolecules

Su, Lin Hui (2002) The folding pathway and core structure assembly of a group II intron ribozyme

Sun, Yu (2002) Mechanism of glutamate receptor activation and desensitization : study of the GluR2 receptor ligand-binding core

2001 DISSERTATIONS

Armstrong, Neali (2001) Mechanisms for activation, antagonism and allosteric modulation of an AMPA receptor : structure-function studies on the GluR2 ligand binding core

Kroenke, Christopher (2001) Dynamics of Escherichia coli ribonuclease H studies by 15N spin relaxation

Senger, Kate (2001) The role of interferon regulatory factors (IRFs) in gene regulation

Xiang, Zhexin (2001) Advances in homology modeling

2000 DISSERTATIONS

Chu, Vi Tuong (2000) Mechanism of branch-point selection in a catalytic group II intron

Irikura, Vera (2000) Understanding the in vivo role of the interleuki-1 receptor antagonist : a reverse genetic approach in mice

Ryoo, Hyung Don (2000) Regulation of Hox downstream target genes by Hox/Exd/Hth

Stauber, Deborah (2000) Structural analysis by x-ray crystallography of the fibroblast growth factor receptor bound to its ligand

Viadiu-Ilarraza, Hector (2000) Structural study of specificity and catalysis by restriction endonuclease BamHI

1999 DISSERTATIONS

Abramovitz, Dana (1999) Investigating a group II intron active site component : structure/function studies of Domain 5

Chin, Kevin (1999) Investigating RNA structure and function through kinetic analysis and electrostatics calculations

Green, Justin (1999) Probing group II intron structure and function through kinetic analysis and nucleotide modification

Hitz, Benjamin (1999) Molecular recognition : from statistical mechanics to statistics of protein interfaces

Leung, Conrad (1999) Molecular and cellular studies of the neuronal cytoskeleton

Michels, William (1999) A family of ribozymes derived from a group II intron : kenetic characterization and structure/function relationships in substrate recognition and cleavage site choice

Stuart, Ashley (1999) Structural and biochemical studies of Nun : an arginine rich RNA-binding protein

Watnick, Randolph (1999) Biochemical mechanisms of coliphage HK022 Nun-medicated transcription termination

Yie, Junming (1999) Transcriptional regulation of the interferon-beta gene

Yu, Jin (1999) Studies on the regulation and function of c-Myc

Zou, Xiaoming (1999) v-Abl tyrosine kinase in signal transduction and cell cycle regulation

1998 DISSERTATIONS

Belluscio, Leonardo (1998) Signal transduction and axonal projections in the mammalian olfactory system

Carr, Peter (1998) Protein dynamics studied by NMR spin relaxation : fibronectin, tenascin, and GCN4

Jacobson, Eric Michael (1998) Structure of the pituitary specific protein, Pit-1, complexed to different DNA elements

Soh, Jae-Won (1998) Studies on the roles of specific isoforms of PKC in mitogenic signal transduction pathways and growth control

Wah, David Alan (1998) Structural study of the type IIs restriction endonuclease FokI

Wen, Chenhui (1998) Analysis of sup-17 and sel-9, two genes that influence lin-12 activity in Caenorhabditis elegans

1997 DISSERTATIONS

Burkholder, William Fox (1997) Mutational analysis of the interactions of Escherichia coli DnaK with substractes and cofactors

Cuff, Marianne Elaine (1997) Crystal structure of a molluscan hemocyanin

Hung, Siu Chung (1997) Biochemical studies of transcription factor Nun of bacteriophage HK022

Mandel, Arthur Michael (1997) Dynamics of Escherichia coli ribonuclease H studied by NMR spin relaxation : temperature dependence of motions on multiple time scales

Winter, Christopher G. (1997) Molecular and genetic studies of ciliary neurotrophic factor

Yamaguchi, Hiroto (1997) Crystallographic studies on human lymphocyte kinase, Lck

1996 DISSERTATIONS

Bharadwaj, Ranganathan (1996) The calculation of binding free energies : application to structure-based drug design

Shapiro, Lawrence Stewart (1996) Structural studies of cell adhesion molecules

1995 DISSERTATIONS

Rosen, Mark Alan (1995) Conformation of two unusual tertiary DNA structures, bulge-loop duplexes and three-stranded junctions, as determined through high-resolution, multidimensional nulcear magnetic resonance spectroscopuy and computational methods

Sampogna, Rosemary Vittoria (1995) Investigation of protein function using poisson-Boltzmann electrostatics

1994 DISSERTATIONS

Hecht, Jonathan (1994) Calculation of the free energy of ligand binding to DNA

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